Usually alcohol does not affect how well an antibiotic works to fight an infection, but the combination may lead to unpleasant side effects. In some cases levels of a drug in commission paid meaning your bloodstream might be changed which could alter effectiveness. Mixing alcohol and some antibiotics may cause side effects like liver problems or a "disulfiram-like reaction". Some antibiotics cannot be taken with alcohol at all, so follow your healthcare provider's instructions.
Levaquin (Levofloxacin) and Alcohol
The effect of the PK of the amoxicillin-alcohol interaction was studied in eight healthy volunteers receiving, on three separate occasions, amoxicillin (500 mg) with water or alcohol. The absorption of amoxicillin, when combined with alcohol, was delayed compared to its absorption with administration with water (11). This was demonstrated by an increased lag time, time to maximal concentration (Tmax), and half-life. Delay…